Journal: Anesthesiology and Perioperative Science

Article Title: Neurophysiological differences between dexmedetomidine sedation and natural sleep across the rodent lifespan: implications for aging and perioperative brain health

doi: 10.1007/s44254-025-00161-y

Figure Lengend Snippet: Dexmedetomidine produced electrophysiological signatures distinct from natural sleep and wake states in young adult and aged mice. The overall amplitude of the EEG in aged mice was smaller (zoomed in vertically to see the oscillations better) compared to young adult mice. Following dexmedetomidine administration, high-voltage spikes appear in the prefrontal cortex EEG and are lower in amplitude in the parietal cortex, see inset diagram for electrode locations. High-voltage spikes gradually reduce in frequency and form high-amplitude delta waves early in the recording, transitioning later into lower amplitude delta waves with the high frequencies attenuated. Panel A shows comparisons between prefrontal cortex and parietal cortex channels from the same young adult mouse under different sleep and dexmedetomidine induced states. Panel B shows the same channels in an aged mouse

Article Snippet: Mice were surgically implanted with a preassembled implant consisting of an 8-channel Neuralynx electrode interface board with 6 EEG electrodes (0.005′′ stainless steel, A-M Systems, Sequim, WA) and 2 EMG electrodes (0.002′′ 7-stranded stainless steel, A-M Systems, Sequim, WA).

Techniques: Produced